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1

Structure of the Stapled p53 Peptide Bound to Mdm2

Baek, Sohee, Kutchukian, Peter S., Verdine, Gregory L., Huber, Robert, Holak, Tad A., Lee, Ki Won, Popowicz, Grzegorz M.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 3.26 MB

english, 2012

2

Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists

Anna Czarna, Barbara Beck, Stuti Srivastava, Grzegorz M. Popowicz, Siglinde Wolf, Yijun Huang, Michal Bista, Tad A. Holak, Alexander Dömling

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 911 KB

english, 2010

3

Jetzt wird es ernst: strukturbasiertes Design von Mdm2/Mdmx-p53-Inhibitoren

Dr. Grzegorz M. Popowicz, Prof. Alexander Dömling, Dr. Tad A. Holak

Journal:

Angewandte Chemie

Year:

2011

Language:

german

File:

PDF, 811 KB

german, 2011

4

Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists

Anna Czarna, Barbara Beck, Stuti Srivastava, Grzegorz M. Popowicz, Siglinde Wolf, Yijun Huang, Michal Bista, Tad A. Holak, Alexander Dömling

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 929 KB

english, 2010

5

The Structure-Based Design of Mdm2/Mdmx–p53 Inhibitors Gets Serious

Dr. Grzegorz M. Popowicz, Prof. Alexander Dömling, Dr. Tad A. Holak

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 808 KB

english, 2011

6

Structural Ramification for Acetyl-Lysine Recognition by the Bromodomain of Human BRG1 Protein, a Central ATPase of the SWI/SNF Remodeling Complex

Mahavir Singh, Grzegorz M. Popowicz, Marcin Krajewski, Tad A. Holak

Journal:

Year:

2007

Language:

english

File:

PDF, 608 KB

english, 2007

7

ChemInform Abstract: The Structure-Based Design of Mdm2/Mdmx—p53 Inhibitors Gets Serious

Grzegorz M. Popowicz, Alexander Doemling, Tad A. Holak

Journal:

Year:

2011

File:

PDF, 18 KB

2011

8

Exhaustive Fluorine Scanning toward Potent p53–Mdm2 Antagonists

Yijun Huang, Siglinde Wolf, Dr. David Koes, Grzegorz M. Popowicz, Prof. Carlos J. Camacho, Prof. Tad A. Holak, Prof. Alexander Dömling

Journal:

Year:

2012

Language:

english

File:

PDF, 678 KB

english, 2012

9

Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing

Mishra, Shravan Kumar, Ammon, Tim, Popowicz, Grzegorz M., Krajewski, Marcin, Nagel, Roland J., Ares, Manuel, Holak, Tad A., Jentsch, Stefan

Journal:

Year:

2011

Language:

english

File:

PDF, 657 KB

english, 2011

10

The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization

BENZINGER, Anne, POPOWICZ, Grzegorz M, JOY, Joma K, MAJUMDAR, Sudipta, HOLAK, Tad A, HERMEKING, Heiko

Journal:

Year:

2005

Language:

english

File:

PDF, 3.37 MB

english, 2005

11

Letter to the Editor:1H,15N and13C NMR Resonance Assignments of Staphostatin A, a SpecificStaphylococcus AureusCysteine Proteinase Inhibitor

Grzegorz Dubin, Grzegorz Popowicz, Marcin Krajewski, Jan Potempa, Adam Dubin, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2004

Language:

english

File:

PDF, 81 KB

english, 2004

12

NMR structural characterization of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) fromDictyostelium discoideum

Chrystelle Mavoungou, Lars Israel, Till Rehm, Dorota Ksiazek, Marcin Krajewski, Grzegorz Popowicz, Angelika A. Noegel, Michael Schleicher, Tad A. Holak

Journal:

Journal of Biomolecular NMR

Year:

2004

Language:

english

File:

PDF, 915 KB

english, 2004

13

The p53-MDM2/MDMX axis – A chemotype perspective

Khoury, Kareem, Popowicz, Grzegorz M., Holak, Tad A., Dömling, Alexander

Journal:

Year:

2011

Language:

english

File:

PDF, 710 KB

english, 2011

14

Structural Basis for the Regulation of Insulin-like Growth Factors by IGF Binding Proteins

Igor Siwanowicz, Grzegorz M. Popowicz, Magdalena Wisniewska, Robert Huber, Klaus-Peter Kuenkele, Kurt Lang, Richard A. Engh, Tad A. Holak

Journal:

Year:

2005

Language:

english

File:

PDF, 776 KB

english, 2005

15

NMR Structural Characterization and Computational Predictions of the Major Intermediate in Oxidative Folding of Leech Carboxypeptidase Inhibitor

Joan L. Arolas, Loyola D’Silva, Grzegorz M. Popowicz, Francesc X. Aviles, Tad A. Holak, Salvador Ventura

Journal:

Year:

2005

Language:

english

File:

PDF, 436 KB

english, 2005

16

Filamins: promiscuous organizers of the cytoskeleton

Grzegorz M. Popowicz, Michael Schleicher, Angelika A. Noegel, Tad A. Holak

Journal:

Trends in Biochemical Sciences

Year:

2006

Language:

english

File:

PDF, 9.37 MB

english, 2006

17

Molecular Structure of the Rod Domain of Dictyostelium Filamin

Grzegorz M. Popowicz, Rolf Müller, Angelika A. Noegel, Michael Schleicher, Robert Huber, Tad A. Holak

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 824 KB

english, 2004

18

The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode

Joan L. Arolas, Grzegorz M. Popowicz, Julia Lorenzo, Christian P. Sommerhoff, Robert Huber, Francesc X. Aviles, Tad A. Holak

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 584 KB

english, 2005

19

Study of a Major Intermediate in the Oxidative Folding of Leech Carboxypeptidase Inhibitor: Contribution of the Fourth Disulfide Bond

Joan L. Arolas, Grzegorz M. Popowicz, Sílvia Bronsoms, Francesc X. Aviles, Robert Huber, Tad A. Holak, Salvador Ventura

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 630 KB

english, 2005

20

Functional and Structural Characterization of Spl Proteases from Staphylococcus aureus

Grzegorz M. Popowicz, Grzegorz Dubin, Justyna Stec-Niemczyk, Anna Czarny, Adam Dubin, Jan Potempa, Tad A. Holak

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.02 MB

english, 2006

21

Structure of the N-terminal Domain of the FOP (FGFR1OP) Protein and Implications for its Dimerization and Centrosomal Localization

Aleksandra Mikolajka, Xiumin Yan, Grzegorz M. Popowicz, Pawel Smialowski, Erich A. Nigg, Tad A. Holak

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 842 KB

english, 2006

22

Enzymatic Activity of the Staphylococcus aureus SplB Serine Protease is Induced by Substrates Containing the Sequence Trp-Glu-Leu-Gln

Grzegorz Dubin, Justyna Stec-Niemczyk, Magdalena Kisielewska, Katarzyna Pustelny, Grzegorz M. Popowicz, Michal Bista, Tomasz Kantyka, Kevin T. Boulware, Henning R. Stennicke, Anna Czarna, Mullika Phop

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.42 MB

english, 2008

23

Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction

Bista, Michal, Wolf, Siglinde, Khoury, Kareem, Kowalska, Kaja, Huang, Yijun, Wrona, Ewa, Arciniega, Marcelino, Popowicz, Grzegorz M., Holak, Tad A., Dömling, Alexander

Journal:

Year:

2013

Language:

english

File:

PDF, 1.66 MB

english, 2013

24

Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus

Burchacka, Ewa, Zdzalik, Michal, Niemczyk, Justyna-Stec, Pustelny, Katarzyna, Popowicz, Grzegorz, Wladyka, Benedykt, Dubin, Adam, Potempa, Jan, Sienczyk, Marcin, Dubin, Grzegorz, Oleksyszyn, Jozef

Journal:

Protein Science

Year:

2014

Language:

english

File:

PDF, 294 KB

english, 2014

25

Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin

Baek, Sohee, Kang, Nam Joo, Popowicz, Grzegorz M., Arciniega, Marcelino, Jung, Sung Keun, Byun, Sanguine, Song, Nu Ry, Heo, Yong-Seok, Kim, Bo Yeon, Lee, Hyong Joo, Holak, Tad A., Augustin, Martin, Bo

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

26

Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities

Huang, Yijun, Wolf, Siglinde, Beck, Barbara, Köhler, Lisa-Maria, Khoury, Kareem, Popowicz, Grzegorz M., Goda, Sayed K, Subklewe, Marion, Twarda, Aleksandra, Holak, Tad A., Dömling, Alexander

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 4.87 MB

english, 2014

27

NMR Screening for Lead Compounds Using Tryptophan-Mutated Proteins

Rothweiler, Ulli, Czarna, Anna, Weber, Lutz, Popowicz, Grzegorz M., Brongel, Kinga, Kowalska, Kaja, Orth, Michael, Stemmann, Olaf, Holak, Tad A.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 375 KB

english, 2008

28

A Novel Class of Cysteine Protease Inhibitors: Solution Structure of Staphostatin A from Staphylococcus aureus †

Dubin, Grzegorz, Krajewski, Marcin, Popowicz, Grzegorz, Stec-Niemczyk, Justyna, Bochtler, Matthias, Potempa, Jan, Dubin, Adam, Holak, Tad A.

Journal:

Year:

2003

Language:

english

File:

PDF, 246 KB

english, 2003

29

Structural basis for the assembly of the Sxl–Unr translation regulatory complex

Hennig, Janosch, Militti, Cristina, Popowicz, Grzegorz M., Wang, Iren, Sonntag, Miriam, Geerlof, Arie, Gabel, Frank, Gebauer, Fátima, Sattler, Michael

Journal:

Year:

2014

Language:

english

File:

PDF, 10.14 MB

english, 2014

30

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery

Popowicz, Grzegorz M., Czarna, Anna, Wolf, Siglinde, Wang, Kan, Wang, Wei, Dömling, Alexander, Holak, Tad A.

Journal:

Year:

2010

Language:

english

File:

PDF, 624 KB

english, 2010

31

A mechanistic study into the epoxidation of carboxylic acid and alkene in a mono, di-acylglycerol lipase

Wang, Xuping, Tang, Qingyun, Popowicz, Grzegorz Maria, Yang, Bo, Wang, Yonghua

Journal:

Biochemical and Biophysical Research Communications

Year:

2015

Language:

english

File:

PDF, 427 KB

english, 2015

32

Conversion of a Mono- and Diacylglycerol Lipase into a Triacylglycerol Lipase by Protein Engineering

Lan, Dongming, Popowicz, Grzegorz Maria, Pavlidis, Ioannis V., Zhou, Pengfei, Bornscheuer, Uwe T., Wang, Yonghua

Journal:

Year:

2015

Language:

english

File:

PDF, 829 KB

english, 2015

33

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

Popowicz, Grzegorz, Czarna, Anna, Holak, Tad

Journal:

Year:

2008

Language:

english

File:

PDF, 413 KB

english, 2008

34

Molecular Basis for the Inhibition of p53 by Mdmx

Popowicz, Grzegorz M., Czarna, Anna, Rothweiler, Ulli, Szwagierczak, Aleksandra, Krajewski, Marcin, Weber, Lutz, Holak, Tad A.

Journal:

Year:

2007

Language:

english

File:

PDF, 792 KB

english, 2007

35

High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

Czarna, Anna, Popowicz, Grzegorz M., Pecak, Aleksandra, Wolf, Siglinde, Dubin, Grzegorz, Holak, Tad A.

Journal:

Year:

2009

Language:

english

File:

PDF, 865 KB

english, 2009

36

Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation

Anna M. Ducka, Peteranne Joel, Grzegorz M. Popowicz, Kathleen M. Trybus, Michael Schleicher, Angelika A. Noegel, Robert Huber, Tad A. Holak and Tomasz Sitar

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.57 MB

english, 2010

37

Discovery of novel dual inhibitors against Mdm2 and Mdmx proteins by in silico approaches and binding assay

Golestanian, Sahand, Sharifi, Amirhossein, Popowicz, Grzegorz M., Azizian, Homa, Foroumadi, Alireza, Szwagierczak, Aleksandra, Holak, Tad A., Amanlou, Massoud

Journal:

Year:

2016

Language:

english

File:

PDF, 1.81 MB

english, 2016

38

Characterization of 14-3-3sigma Dimerization Determinants: Requirement of Homodimerization for Inhibition of Cell Proliferation

Verdoodt, Berlinda, Benzinger, Anne, Popowicz, Grzegorz M., Holak, Tad A., Hermeking, Heiko

Journal:

Year:

2006

Language:

english

File:

PDF, 1.11 MB

english, 2006

39

Lid mobility in lipase SMG1 validated using a thiol/disulfide redox potential probe

Guo, Shaohua, Popowicz, Grzegorz Maria, Li, Daoming, Yuan, Dongjuan, Wang, Yonghua

Journal:

Year:

2016

Language:

english

File:

PDF, 613 KB

english, 2016

40

Selective activators of protein phosphatase 5 target the autoinhibitory mechanism

Haslbeck, Veronika, Drazic, Adrian, Eckl, Julia, Alte, Ferdinand, Helmuth, Martin, Popowicz, Grzegorz, Schmidt, Werner, Braun, Frank, Weiwad, Matthias, Fischer, Gunter, Gemmecker, Gerd, Sattler, Micha

Journal:

Bioscience Reports

Year:

2015

Language:

english

File:

PDF, 919 KB

english, 2015

41

Comparison of enzymatic properties and small molecule inhibition of γ–glutamyltranspeptidases from pathogenic and commensal bacteria

Bolz, Christian, Bach, Nina C., Meyer, Hannelore, Müller, Gerhard, Dawidowski, Maciej, Popowicz, Grzegorz, Sieber, Stephan A., Skerra, Arne, Gerhard, Markus

Journal:

Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 879 KB

english, 2016

42

Lipase-Driven Epoxidation Is A Two-Stage Synergistic Process

Tang, Qingyun, Popowicz, Grzegorz M., Wang, Xuping, Liu, Jinsong, Pavlidis, Ioannis V., Wang, Yonghua

Journal:

ChemistrySelect

Year:

2016

Language:

english

File:

PDF, 780 KB

english, 2016

43

Identification of small-molecule inhibitors of USP2a

Tomala, Marcin D., Magiera-Mularz, Katarzyna, Kubica, Katarzyna, Krzanik, Sylwia, Zieba, Bartosz, Musielak, Bogdan, Pustula, Marcin, Popowicz, Grzegorz M., Sattler, Michael, Dubin, Grzegorz, Skalniak,

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 2.66 MB

english, 2018

44

Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

Koes, David, Khoury, Kareem, Huang, Yijun, Wang, Wei, Bista, Michal, Popowicz, Grzegorz M., Wolf, Siglinde, Holak, Tad A., Dömling, Alexander, Camacho, Carlos J., Xue, Bin

Journal:

Year:

2012

Language:

english

File:

PDF, 560 KB

english, 2012

45

Targeting TRAF6 E3 ligase activity with a small molecule inhibitor combats autoimmunity

Brenke, Jara Kerstin, Popowicz, Grzegorz Maria, Schorpp, Kenji, Rothenaigner, Ina, Roesner, Manfred, Meininger, Isabel, Kalinski, Cédric, Ringelstetter, Larissa, R’kyek, Omar, Jürjens, Gerrit, Vincend

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 3.52 MB

english, 2018

46

NMR fragment-based screening for development of the CD44-binding small molecules

Pustuła, Marcin, Czub, Mirosława, Łabuzek, Beata, Surmiak, Ewa, Tomala, Marcin, Twarda-Clapa, Aleksandra, Guzik, Katarzyna, Popowicz, Grzegorz M., Holak, Tad A.

Journal:

Bioorganic Chemistry

Year:

2018

Language:

english

File:

PDF, 1.47 MB

english, 2018

47

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

Pabis, Marta, Popowicz, Grzegorz M, Stehle, Ralf, Fernández-Ramos, David, Asami, Sam, Warner, Lisa, García-Mauriño, Sofía M, Schlundt, Andreas, Martínez-Chantar, María L, Díaz-Moreno, Irene, Sattler,

Journal:

Nucleic Acids Research

Year:

2018

Language:

english

File:

PDF, 7.37 MB

english, 2018

48

The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation

Ostertag, Michael Sebastian, Messias, Ana Cristina, Sattler, Michael, Popowicz, Grzegorz Maria

Journal:

Year:

2018

Language:

english

File:

PDF, 2.42 MB

english, 2018

49

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development

Kalel, Vishal C, Mäser, Pascal, Sattler, Michael, Erdmann, Ralf, Popowicz, Grzegorz M

Journal:

Current Opinion in Microbiology

Year:

2018

Language:

english

File:

PDF, 835 KB

english, 2018

50

Structure and characterization of Aspergillus fumigatus lipase B with a unique, oversized regulatory subdomain

Huang, Weiqian, Lan, Dongming, Popowicz, Grzegorz M., Zak, Krzysztof M., Zhao, Zexin, Yuan, Hong, Yang, Bo, Wang, Yonghua

Journal:

Year:

2019

Language:

english

File:

PDF, 1.66 MB

english, 2019

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